Journal
TETRAHEDRON
Volume 66, Issue 27-28, Pages 5082-5088Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2010.04.115
Keywords
Organocatalysis; Ionic liquids; Amino acids; Asymmetric synthesis; Aldol reaction
Categories
Funding
- Deutsche Forschungsgemeinschaft (DFG)
Ask authors/readers for more resources
New amino acid-1,2,3-triazolium conjugates were synthesized by establishing a 1,2,3-triazolium unit to the amino acid through Cu-catalyzed alkyne-azide cycloaddition and subsequent N-methylation. These products were applied as ionic-liquid-tagged organocatalysts in asymmetric direct aldol reactions. Remarkably, a lysine-derived conjugate performed better than proline derivatives. Evidence was found that IL-tagging improved the catalytic performance. Recycling of the organocatalyst was easily possible by extraction of products. (C) 2010 Elsevier Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available