Journal
TETRAHEDRON
Volume 66, Issue 18, Pages 3326-3331Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2010.02.097
Keywords
Dendrimers; Mannose; Carbosilane; Dendritic cells
Categories
Funding
- Fondo de Investigacion Sanitaria (FIS) of Ministerio de Ciencia e Innovacion FIS [PI052476, PI061479]
- Fundacion para la Investigacion y la Prevencion del SIDA en Espana (FIPSE) [24632/07]
- MNT-ERA NET [NAN2007-31135-E]
- Red RIS [RD06-0006-0035]
- Fundacion Caja Navarra and Comunidad de Madrid [S-SAL-0159-2006]
- Fondo de Investigacion Sanitaria [PI080222]
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A synthetic strategy has been developed for the preparation of new globular carbosilane dendrimers with mannose groups at the periphery. It consists of hydrosilylation reaction of allyl tetraacetylmannose with carbosilane dendrimers containing monohydrosilane end groups and the subsequent deacetylation reaction. Evaluation of dendrimer toxicities in dendritic cells by MTT assay were carried out, and evidence a good biocompatibility. (C) 2010 Elsevier Ltd. All rights reserved.
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