Journal
TETRAHEDRON
Volume 66, Issue 26, Pages 4882-4887Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2010.03.021
Keywords
Oxidative carbonylation; Multicatalysis; Tylophora alkaloids; Antofine; Palladium
Categories
Funding
- Novartis
- FQRNT
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A rapid synthetic approach to the tylophora alkaloids antofine and 13a alpha-secoantofine is presented that makes use of a multicatalytic oxidative aminochlorocarbonylation/Friedel-Crafts reaction as the key step. This reaction, along with a one-pot, three-step telescoped process offers a three or four-pot sequence to access the title compounds in high overall yield. (C) 2010 Elsevier Ltd. All rights reserved.
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