Journal
TETRAHEDRON
Volume 65, Issue 34, Pages 7171-7176Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2009.06.017
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Funding
- Franco-Vietnamese Cooperation program (Study of the flora of Vietnam)
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Two new compounds, a cyclic peptide desmocyclopeptide (1) and a special flavone desmorostratone (2) were isolated from the stem bark of Desmos rostrata, along with two known compounds, desmosdumotins B (3) and C (4). Their Structures were established on the basis of the spectral data, including mass spectrometry and 2D NMR. The total synthesis of desmorostratone (2) was performed in order to confirm its structure as well as that of desmosdumotin C (4), which was a tautomeric mixture in the solution. Finally, cytotoxity of these compounds were evaluated. Desmosdumotin C (4) displayed a moderate inhibition activity against KB cell line with an IC50 of 19.2 mu M, whereas the other products showed a weak inhibition against the same cell line target. (c) 2009 Elsevier Ltd. All rights reserved.
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