Journal
TETRAHEDRON
Volume 65, Issue 5, Pages 998-1004Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2008.11.088
Keywords
Aegle marmelos; Oxazoline; Amides; Antibacterial activity
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Funding
- Higher Education Commission Islamabad, Pakistan
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A rare alkaloid, shahidine (1), having an unstable oxazoline core has been isolated as a major constituent from the fresh leaves of Aegle marmelos. It is moisture-sensitive, and found to be the parent compound of aegeline and other amides, however. it is stable in dimethyl sulfoxide. Its structure was established by spectroscopic analysis. Biogenetically, oxazolines may be considered as the precursor of hydroxy amides and oxazoles found in plants. Shahidine (1) showed activity against a few Gram-positive bacteria. (C) 2008 Elsevier Ltd. All rights reserved.
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