Journal
TETRAHEDRON
Volume 65, Issue 9, Pages 1859-1870Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2008.10.109
Keywords
Gold; Propargylic esters; 1,3-Dienes; Naphthalenes
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Funding
- National Institutes of Health [GM64444]
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A novel gold(I)-catalyzed cascade cycloisomerization of a variety of propargylic esters leading to unsymmetrically Substituted naphthalenes has been developed. This domino process involves ail unprecedented tandem sequence of 1,3- and 1,2-migrations of two substantially different migrating groups. It is believed that this transformation proceeds via formation of 1,3-diene intermediate or its equivalent, which, upon carbocyclization and aromatization steps, transforms into the naphthalene skeleton. In addition, it was also demonstrated that a variety of 1,3-dienes can be accessed stereoselectively via the 1,3-migration-proton transfer cascade. (C) 2008 Elsevier Ltd. All rights reserved.
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