Journal
TETRAHEDRON
Volume 65, Issue 21, Pages 4173-4181Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2009.03.045
Keywords
Lipodepsipeptide; Viscosin group; Pseudodesmin; Pseudomonas; Plethodontidae; X-ray structure; NMR
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Funding
- Belgian National Fund for Scientific Research [G.0365.03, G.0064.07]
- Ghent University
- Free University of Brussels (VUB)
- University of Antwerp via the 'Zware Apparatuur' Incentive of the Flemish Government
- NMR Scientific Research Community
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Two new cyclic lipodepsipeptides named pseudodesmins A and B have been isolated from Pseudomonas bacteria collected from the mucus layer in the skin of the black belly salamander. Both compounds show moderate antibacterial activity against Gram positive bacteria, including MRSA. Complete (1)H, (13)C and (15)N NMR assignment of both compounds afforded their covalent structure and served to guide the analysis of 1,C-MS and X-ray diffraction data from which the final stereochemistry could be established. Both molecules Call be categorized as new members of the viscosin group of cyclic lipodepsipeptides. (C) 2009 Elsevier Ltd. All rights reserved.
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