Journal
TETRAHEDRON
Volume 65, Issue 1, Pages 344-350Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2008.10.045
Keywords
2-Amino-5-alkylidene-thiazol-4-one; Rhodanine; Knoevenagel condensation; Multi-component reaction; Parallel synthesis; Microwave-assisted organic synthesis
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Funding
- European Union [LSHM-CT 2004-512138]
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A fast and straightforward three-component reaction to 2-amino-5-alkylidene-thiazol-4-ones is described. The one-pot methodology, reported for the first time, involves Knoevenagel condensation of aromatic aldehydes and rhodanine followed by displacement of the thiocarbonyl sulfur with primary or secondary amines in the same reaction mixture. The reactions were performed using a dedicated microwave reactor, which enabled short reaction times and easy work-up. (C) 2008 Elsevier Ltd. All rights reserved.
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