Journal
TETRAHEDRON
Volume 65, Issue 36, Pages 7580-7586Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2009.06.125
Keywords
Chaetomugilin; Chaetomium globosum; Growth inhibition; Marine fish; CD spectrum; Absolute stereostructure; COMPARE program
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Funding
- Ministry of Education, Culture, Sports, Science and Technology, Japan
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Chaetomugilins I-O were isolated from a strain of Chaetomium globosum originally isolated from the marine fish Mugil cephalus, and their absolute stereostructures were elucidated on the basis of spectroscopic analyses, including 1D and 2D NMR techniques, as well as chemical transformations. These compounds exhibited significant growth inhibition of cultured P388, HL-60, L1210, and KB cell lines. In addition, chaetomugilin I showed selective cytotoxic activity against 39 human cancer cell lines. (C) 2009 Elsevier Ltd. All rights reserved.
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