Journal
TETRAHEDRON
Volume 65, Issue 7, Pages 1444-1449Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2008.12.008
Keywords
Aldol reaction; Homoproline; Michael reaction; Organocatalysis; Sulfonamides
Categories
Funding
- European Social Fund
- National Resources
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Sulfonamides of the non-natural amino acid homoproline and the dipeptide Pro-Phe were synthesised and evaluated for their catalytic activity in Michael and aldol reactions. Sulfonamides of homoproline outperform proline and Pro-Phe in the Michael reaction, whereas sulfonamides of Pro-Phe lead to better results in the aldol reaction. The results of the present study show that the conversion of the carboxylic group of either homoproline or dipeptide Pro-Phe to the bioisosteric acyl sulfonamide group lead to improved organocatalysts. (C) 2008 Elsevier Ltd. All rights reserved.
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