Journal
TETRAHEDRON
Volume 65, Issue 44, Pages 9002-9007Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2009.06.103
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Funding
- EPSRC
- GlaxoSmithKline [EP/E020712/1]
- Royal Society Industry Fellow
- EPSRC [EP/E020712/1] Funding Source: UKRI
- Engineering and Physical Sciences Research Council [GR/S99419/01, EP/E020712/1] Funding Source: researchfish
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An efficient and convergent one-step synthesis of substituted dihydroquinolin-2-ones from alpha,beta-unsaturated esters and aminoaryl pinacolboronates under rhodium catalysis is reported. The reaction is easily applicable in parallel synthesis format and provides convenient access to this pharmaceutically-relevant motif. (C) 2009 Elsevier Ltd. All rights reserved.
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