Journal
TETRAHEDRON
Volume 65, Issue 22, Pages 4351-4355Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2009.03.073
Keywords
Direct cyanation; alpha-Aryl alcohols; alpha-Aryl thiols; Lewis acid
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Funding
- Inha University
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Various alpha-aryl nitriles have been prepared in excellent yield from the corresponding alpha-aryl alcohols employing 3 mol % of B(C6F5)(3) (1) as Lewis acid catalyst and (CH3)(3)SiCN (TMSCN) as cyanide source. Cyano transfer from TMSCN to alcohol proceeds within short reaction time at rt. alpha-Aryl thiols also produce corresponding nitriles in good to excellent yield at reflux condition. (C) 2009 Elsevier Ltd. All rights reserved.
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