Journal
TETRAHEDRON
Volume 65, Issue 27, Pages 5409-5412Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2009.04.046
Keywords
Capsaicin analogue; Vanillylamine; Acylation
Categories
Funding
- Laboratory of Organic Functional Molecules
- Sino-French Institute
- ECNU
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Highly efficient synthesis of capsaicin analogues was developed using condensation of vanillylamine with acyl chlorides in a biphase H2O/CHCl3 System under mild conditions. For C-4-C-18 aliphatic or aromatic acyl chlorides, the yields were up to 93-96% with high purity after a simple work-up procedure, and only 1-1.16 equiv of acyl chloride was needed in the reaction. (C) 2009 Elsevier Ltd. All rights reserved.
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