Journal
TETRAHEDRON
Volume 65, Issue 26, Pages 4957-4967Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2009.03.103
Keywords
-
Categories
Funding
- NIH [GM-079339]
- Boehringer-Ingelheim
- Bristol Myers Squibb
- Eli Lilly
- Packard Foundation
- Beckman Foundation
- Sloan Foundation
Ask authors/readers for more resources
An N-heterocyclic carbene (NHC) catalyzed intramolecular lactonization to prepare densely functionalized bicyclic gamma-lactam-gamma-lactone adducts from enals is reported. This method has been applied to the formal synthesis of salinosporamide A, a potent 20S proteasome inhibitor and anti-cancer therapeutic. (C) 2009 Elsevier Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available
Share Paper
