Journal
TETRAHEDRON
Volume 65, Issue 5, Pages 1026-1032Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2008.11.071
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Funding
- National Natural Science Foundation of China [20775069]
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A Mannich-type three-component reaction involving aldehydes, acetamide, and enolizable ketones or beta-keto esters for the preparation of beta-acetamido carbonyl compounds in the presence of TMSCl is described. This newly developed protocol is operationally convenient, widely applicable, and highly diastereoselective. (C) 2008 Elsevier Ltd. All rights reserved.
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