Journal
TETRAHEDRON
Volume 65, Issue 33, Pages 6712-6719Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2008.10.060
Keywords
Natural product; Alkaloid; Heck reaction; Carbonylation; Amidines
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A strategy for a total synthesis of the marine alkaloid perophoramidine has been investigated. Key steps which have been tested include a tandem intramolecular Heck/carbonylation reaction and a stereoselective allylation of a pentacyclic delta-lactam to produce the C-4/20 vicinal quaternary centers having the requisite relative configuration of the metabolite. (C) 2008 Published by Elsevier Ltd.
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