Journal
TETRAHEDRON
Volume 65, Issue 43, Pages 8808-8815Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2009.08.077
Keywords
Berkleasmium nigroapicale; Eremophilane; Cytotoxicity; Antimalarial activity; Saprobic fungi
Categories
Funding
- National Center for Genetic Engineering and Biotechnology (BIOTEC)
Ask authors/readers for more resources
Berkleasmins A-E, five new eremophilane sesquiterpenoids were isolated from the saprobic fungus Berkleasmium nigroapicale BCC 8220. The structures of the new compounds were elucidated by analyses of NMR spectroscopic and mass spectrometry data in combination with chemical means. Berkleasmins A and C exhibited cytotoxic activity against cancer cell-lines (NCI-H187, MCF-7, and KB) as well as nonmalignant Vero cells with IC(50) values of 1.1-7.5 mu g/mL, and these compounds also showed antimalarial activity with respective IC(50) of 3.1 and 2.8 mu g/mL. (c) 2009 Elsevier Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available