4.4 Article

Propylphosphonic anhydride (T3P®): an efficient reagent for the one-pot synthesis of 1,2,4-oxadiazoles, 1,3,4-oxadiazoles, and 1,3,4-thiadiazoles

Journal

TETRAHEDRON
Volume 65, Issue 48, Pages 9989-9996

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2009.09.114

Keywords

Propylphosphonic anhydride; 1,2,4-Oxadiazole; 1,3,4-Thiadiazole; Diacylhydrazide; Cyclodehydration

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Propylphosphonic anhydride (T3P (R)) has been demonstrated to be all efficient and mild reagent for the one-pot synthesis of 1,2,4-oxadiazoles, 1,3,4-oxadiazoles, and 1,3,4-thiadiazoles from carboxylic acids. (C) 2009 Elsevier Ltd. All rights reserved.

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