Journal
TETRAHEDRON
Volume 65, Issue 22, Pages 4298-4303Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2009.03.051
Keywords
Hyperbranched polymer; Phosphohydrolase; Pyrophosphate sensor
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Funding
- Clemson University Department of Chemistry
- Center for Optical Materials Science and Engineering Technologies
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Phosphotriesterase models incorporating di(2-picolyl)amino ligands supported by m-xylylene or 2-hydroxy-m-xylylene scaffolds have been tethered to the periphery of a water-soluble hyperbranched polyglycerol (PG). In aqueous solution buffered at pH 7.4, the polymeric complexes of Zn2+ are useful receptors for polymeric indicator displacement assays for phosphate and pyrophosphate employing commercial complexometric indicators. Under the same conditions, the Co3+ effectively hydrolyze p-nitrophenylphosphate with approximately five orders of magnitude rate enhancement versus uncatalyzed hydrolysis. These systems offer promising results as mixed-metal dual detect-decontaminate materials for organophosphorus toxins under mild, neutral aqueous conditions. (C) 2009 Elsevier Ltd. All rights reserved.
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