Journal
TETRAHEDRON
Volume 64, Issue 49, Pages 11050-11057Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2008.09.075
Keywords
Titanocene(III) chloride; Dihydroisocoumarins; Radical; Natural products; Synthesis
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Funding
- DST, New Delhi
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A radical-promoted synthesis of 3,4-dihydroisocoumarins has been achieved in moderate to good yields using titanocene(III) chloride (Cp2TiCl) as the radical initiator. The total synthesis of four naturally occurring dihydrocoumarins hydrangenol, phyllodulcin, macrophyllol and thunberginol G has been accomplished using the radical technology. Cp2TiCl was prepared in situ from commercially available titanocene dichloride (Cp2TiCl2) and Zn-dust in THF under argon. (C) 2008 Elsevier Ltd. All rights reserved.
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