Journal
TETRAHEDRON
Volume 64, Issue 35, Pages 8059-8066Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2008.06.080
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Funding
- La Ligue Contre le Cancer Comite du Loiret
- La Federation pour la Recherche Medicale Comite d'Orleans
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In the course of our investigations on the synthesis of original nitrogen heterocyclic derivatives, we were interested in the synthesis and study of original 1,4-dihydropyrazine rings. To this aim the desired bis-vinylphosphate derivative was prepared from N-Boc piperazine-2,5-dione and then was engaged in palladium catalyzed reactions (reduction, Suzuki and Stille cross-coupling reactions). The 1,4-dihydropyrazine and the corresponding 2,5-disubstituted derivatives were obtained in fair to good yields and were then functionalized under anionic conditions. Aromatization into 1,4-pyrazines was investigated in a second stage.(C) 2008 Elsevier Ltd. All rights reserved.
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