Total synthesis of (±)-stemonamide, (±)-isostemonamide, (±)-stemonamine, and (±)-isostemonamine using a radical cascade

A total synthesis of (+/-)-stemonamide and (+/-)-isostemonamide has been achieved by using a radical cascade that involves two endo-selective cyclizations. (+/-)-Stemonamine and (+/-)-isostemonamine are synthesized by chemoselective reduction of (+/-)-stemonamide and (+/-)-isostemonamide, respectively. (C) 2008 Elsevier Ltd. All rights reserved.