4.4 Article

Direct ortho-arylation of 2-arylbenzoxazoles via C-H activation

Journal

TETRAHEDRON
Volume 64, Issue 28, Pages 6782-6787

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2008.04.099

Keywords

arylation; C-C coupling; palladium catalysis; C-H activation

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A new and highly regioselective arylation of 2-arylbenzoxazoles based on C-H activation has been developed. The results represent the first examples of palladium-catalyzed direct ortho-arylation of 2-arylbenzoxazoles and also provide a facile route for the synthesis of complicated structures containing arylated benzoxazoles moieties. (C) 2008 Elsevier Ltd. All rights reserved.

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