Journal
TETRAHEDRON
Volume 64, Issue 7, Pages 1467-1473Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2007.11.048
Keywords
modified oligonucleotides; perylene diimide; alkynes; azides; catalytic huisgen [3+2] cycloaddition
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Terminal alkyne-containing phosphoramidite and solid support were prepared and used for the synthesis of 5'- and 3'-alkyne-modified oligonucleotides. The copper-catalyzed Huisgen [3+2] cycloaddition reaction in water-DMSO was used for the efficient preparation of perylene diimide-oligonucleotide conjugates suitable for constructing various types of PDI-modified DNA duplexes. (c) 2007 Elsevier Ltd. All rights reserved.
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