4.4 Article

Improved total synthesis of (±)-trans-dihydronarciclasine, devised for large-scale preparation

Journal

TETRAHEDRON
Volume 64, Issue 9, Pages 2172-2177

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2007.12.031

Keywords

cycloaddition reaction; amaryllidaccae; trans-dihydronarciclasine; isocarbostyrils; 3,5-dibromo-2-pyrone

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New synthetic route to (+/-)-trans-dihydronarciclasine, more suitable for a large-scale preparation, has been devised with the early stage incorporation of ester functionality for direct assembly of the B-ring lactam. (C) 2007 Elsevier Ltd. All rights reserved.

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