4.4 Article

One-pot three-component reaction providing 1,5-benzodiazepine derivatives

Journal

TETRAHEDRON
Volume 64, Issue 49, Pages 11034-11040

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2008.09.076

Keywords

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Funding

  1. Scientific Research (A)
  2. Scientific Research for Exploratory Research from Japan Society for the Promotion of Science
  3. Scientific Research on Priority Areas [17035047]
  4. Ministry of Education, Culture, Sports, Science, and Technology, Japan
  5. Japan Society for the Promotion of Science (JSPS)
  6. Grants-in-Aid for Scientific Research [17035047] Funding Source: KAKEN

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The novel one-pot three-component reaction of aromatic aldehydes, 1,2-phenylenediamine, and beta-keto esters is described. This reaction involves the gamma-selective C-C bond formation of beta-keto esters and produces 1,5-benzodiazepine derivatives. (C) 2008 Elsevier Ltd. All rights reserved.

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