Journal
TETRAHEDRON
Volume 64, Issue 42, Pages 9983-9988Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2008.07.101
Keywords
selenoamide; copper(0); deselenation; cyclopropanation; aminocyclopropane; aminocarbene species
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Funding
- Ministry of Education, Culture, Sports, Science and Technology, Japan [19020061, 19350095]
- Grants-in-Aid for Scientific Research [19020061] Funding Source: KAKEN
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Upon heating of a mixture of N,N-disubstituted aromatic selenoamides and several electron-deficient olefins in the presence of copper(0) powder, a novel deselenative cyclopropanation takes place to afford the corresponding aminocyclopropanes in good yields. When acrylonitrile is employed as an electron-deficient olefin, the aminocyclopentanation occurs in preference to the aminocyclopropanation by prolonging the reaction time. The obtained aminocyclopropane derivatives can be converted to the corresponding 1,4-dicarbonyl compounds upon treatment with 2 N HCl. (C) 2008 Elsevier Ltd. All rights reserved.
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