Journal
TETRAHEDRON
Volume 64, Issue 37, Pages 8692-8699Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2008.07.005
Keywords
reactivity; kinetics; pterins; hydrogen peroxide
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Funding
- Consejo Nacional de Investigaciones Cientificas y Tecnicas, CONICET [PIP 6301/05]
- Agencia de Promocion Cientifica y Tecnologica, ANPCyT [PICT 06-12610, PICT 33919]
- Universidad Nacional de La Plata (UNLP)
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In vitiligo, a common skin disorder that produces white patches of depigmentation, 7,8-dihydropterins accumulate in the presence of high concentration of H2O2. In this work, we present a study of the reaction between 7,8-dihydropterins and H2O2. The rate of the reaction, as well as the products formed, strongly depend on the chemical structure of the substituents. Electron-donor groups as substituents are the most reactive derivatives and undergo oxidation of the pterin moiety. The corresponding bimolecular rate constants at 37 degrees C in neutral aqueous solutions are reported. The biological implications of the results obtained are also discussed. (c) 2008 Elsevier Ltd. All rights reserved.
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