Journal
TETRAHEDRON
Volume 64, Issue 18, Pages 3998-4003Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2008.02.046
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A new synthetic approach toward 6a-carba-beta-D-fructopyranose, a non-nutritive sweetener related to topiramate, is described. This scheme uses 2-C-hydroxymethyl-L-erythrose acetonide as starting material and efficiently delivers the target compound applying an RCM protocol for the construction of the carbocycle ring. (c) 2008 Elsevier Ltd. All rights reserved.
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