4.4 Article Proceedings Paper

Synthesis of the putative minimal FGF binding motif heparan sulfate trisaccharides by an orthogonal protecting group strategy

Journal

TETRAHEDRON
Volume 64, Issue 42, Pages 9865-9873

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2008.08.021

Keywords

oligosaccharide synthesis; heparin; heparan sulfate; fibroblast growth factors; binding epitope; orthogonal protection

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The synthesis of two trisaccharides, the putative minimal heparan sulfate sequences responsible for binding to acidic and basic fibroblast growth factors, respectively, is described from a common protected intermediate using an orthogonal protecting group strategy. (C) 2008 Elsevier Ltd. All rights reserved.

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