Journal
TETRAHEDRON
Volume 64, Issue 16, Pages 3477-3482Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2008.02.022
Keywords
organocatalyst; multi-component; 1,4-dihydropyridines; domino synthesis; solvent free
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An organocatalysed protocol for one-pot synthesis of 1,4-dihydropyridines via three-component coupling of cinnamaldehyde, aniline and beta-keto esters under solvent free conditions at ambient temperature is reported. The reaction is generally very fast and the products are obtained in high yield. The catalytic activity of small organic molecules like amino acids (acidic, basic and neutral), ephedrine and cinchona alkaloids was studied. (c) 2008 Elsevier Ltd. All rights reserved.
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