Journal
TETRAHEDRON
Volume 64, Issue 10, Pages 2419-2424Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2008.01.015
Keywords
Grignard reagents; fluoroalkyl groups; Meerwein-Ponndorf-Verley reductions
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Fluorine-containing esters were demonstrated to be convenient substrates for construction of the corresponding ketones by low temperature reaction with Grignard reagents followed by warming up to 0 degrees C, while heating the mixture up to 80 degrees C readily promoted the reduction of the ketones obtained by the generated magnesium alkoxides whose mechanism was speculated as Meerwein-Ponndorf-Verley type reduction by computational technique. (C) 2008 Elsevier Ltd. All rights reserved.
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