Onium salt supported organic synthesis in water: application to Grieco's multicomponent reaction

By using an ammonium chloride salt as water solubilizing moiety, our onium salt supported organic synthesis strategy was extended to water as a solvent. This method allows for high loading capacities both of the supports and their solutions owing to low molecular weight of the onium salts and simplified purification steps as well. (C) 2007 Elsevier Ltd. All rights reserved.