4.4 Article

Formal synthesis of salinosporamide A using a nickel-catalyzed reductive aldol cyclization-lactonization as a key step

Journal

TETRAHEDRON
Volume 64, Issue 34, Pages 7896-7901

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2008.06.038

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Funding

  1. Engineering and Physical Sciences Research Council [GR/T07466/01] Funding Source: researchfish

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Application of a sequential nickel-catalyzed reductive aldol cyclization-lactonization reaction in a short formal synthesis of salinsporamide A, a potent 20S proteasome inhibitor and anti-cancer compound, is described. (C) 2008 Elsevier Ltd. All rights reserved.

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