Journal
TETRAHEDRON
Volume 64, Issue 39, Pages 9309-9314Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2008.07.017
Keywords
Alzheimer disease; thiazole analogues of Tacrine; substituted [1,3]thiazolo[4,5-d]-[1,2,3]triazine; substituted 4-amino-1,3-thiazole-5-carbonitrile; dimethyl cyanodithioimidocarbonate
Categories
Funding
- 'Ministere de l'Education Nationale
- de l'Enseignement Superieur et de la Recherche
- Universite du Luxembourg
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In this work, we described an easy preparation Of substituted 4-amino-5-cyano-1,3-thiazoles. These compounds have been used as starting materials to obtain two classes of compounds. New substituted [1,3]thiazolo[4,5-e]pyridines were synthesized in one step via Friedlander reaction. Diazotation of 4-amino-5-cyano-1,3-thiazoles afforded 4-chloro[1,3]thiazolo[4,5-d][1,2,3]triazines in one step. The later Was substituted by a secondary amine to obtain substituted 4-amino[1,3]thiazolo[4,5-d][1,2,3]triazines. (C) 2008 Elsevier Ltd. All rights reserved.
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