Synthesis of substituted [1,3]thiazolo[4,5-b]pyridines and [1,3]thiazolo-[4,5-d][1,2,3]triazines

In this work, we described an easy preparation Of substituted 4-amino-5-cyano-1,3-thiazoles. These compounds have been used as starting materials to obtain two classes of compounds. New substituted [1,3]thiazolo[4,5-e]pyridines were synthesized in one step via Friedlander reaction. Diazotation of 4-amino-5-cyano-1,3-thiazoles afforded 4-chloro[1,3]thiazolo[4,5-d][1,2,3]triazines in one step. The later Was substituted by a secondary amine to obtain substituted 4-amino[1,3]thiazolo[4,5-d][1,2,3]triazines. (C) 2008 Elsevier Ltd. All rights reserved.