Journal
TETRAHEDRON
Volume 64, Issue 21, Pages 4835-4851Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2008.01.131
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Three new 11 beta-hydroxy C-20 gibberellins have been isolated from immature loquat fruit and their structures were established as 11 beta-hydroxy-GA(12), 11 beta-hydroxy-GA(15) and 11 beta-hydroxy-GA(53), respectively, by direct GC-MS comparisons with authentic samples obtained from gibberellic acid by multistep syntheses. An advanced intermediate (30) was prepared in 20 steps from which 6 11 beta-hydroxy C20 gibberellins were prepared by parallel routes involving up to a further 5 steps for each sequence. The key steps involved a much improved synthesis of gibberellenic acid derivatives, a Lewis acid catalysed cyclisation of a diazoketone, a domino-hydroboration of a diene and oxidative cleavage of a ketone derived enolate. (C) 2008 Elsevier Ltd. All rights reserved.
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