Journal
TELEMEDICINE JOURNAL AND E-HEALTH
Volume 14, Issue 7, Pages 715-719Publisher
MARY ANN LIEBERT, INC
DOI: 10.1089/tmj.2007.0118
Keywords
microelectromechanical systems; gastrointestinal disease; drug delivery
Categories
Funding
- Natural Science Foundation of Chongqing, China [CSTC 2006BA5005]
- National Natural Science Foundation of China [30700160, 30500120]
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A micromachined capsule based on microelectromechanical systems (MEMS) technology is introduced in this paper. It is an effective tool for diagnosing and treating gastrointestinal diseases. The microcapsule can carry out real-time drug release and the gastrointestinal fluid sampling in the gastrointestinal tract. According to the structural and metabolic characters of the gastrointestinal tract, the configuration of the microcapsule was designed as a cylinder. This nondigestible oral device can smoothly pass through the gastrointestinal tract for drug delivery and liquid sampling. The working mechanism of the capsule was the mechanic movement mode of a piston, which was regulated through a MEMS calorific element. The action of drug delivery and gastrointestinal fluid sampling in the gastrointestinal tract was performed wirelessly. The remote control device can be connected with a computer through a serial port (RS-232), and it can be used in telemedicine applications. Some experimental research has been carried out to validate the design. The experimental results indicated that the microcapsule can achieve drug delivery and liquid sample reliably.
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