Journal
TECHNOLOGY IN CANCER RESEARCH & TREATMENT
Volume 12, Issue 4, Pages 275-284Publisher
SAGE PUBLICATIONS INC
DOI: 10.7785/tcrt.2012.500331
Keywords
Bone cancer treatment; Cisplatin; Composite; Drug delivery system; Scaffold; Osteoblast; Bone graft; Multifunctional material
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Funding
- Romanian National Authority for Scientific Research [72-198/2008]
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In this paper, the synthesis and characterization of novel cisplatin-loaded collagen (COLL)/hydroxyapatite (HA) composite materials are presented. The composite materials were designed to obtain a COLL: HA weight ratio close to the bone composition. The content of embedded cisplatin was chosen to assure a concentration of cisplatin of 6 and 10 mu M, respectively, into the culture media used in cell culture experiments. These cisplatin delivery systems were characterized by determining the physico-chemical properties of the composite material, the drug release process as well as their biological activity. Based on the in vitro data that showed the cytotoxic, anti-proliferative and anti-invasive activities of these multifunctional systems on G292 osteosarcoma cells in dependence on the cisplatin concentration released in culture medium, we conclude that the newly developed COLL/HA-cisplatin drug delivery system could be a feasible approach for locoregional chemotherapy of bone cancer.
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