Journal
TALANTA
Volume 120, Issue -, Pages 262-267Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.talanta.2013.12.020
Keywords
Enzyme-mimic nanomaterials; Reactive active species; Ultraviolet irradiation; Cell imaging
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Funding
- NSFC [21127009, 91027037]
- Hunan University 985 Fund
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We have prepared enzyme-mimic Au-Pt nanocomposites (NCs) for catalyzing the decomposition of reactive oxygen species. After surface modification, the Au-Pt NCs can be readily internalized and retained by human skin cells and also can effectively reduce cellular oxidative stress. We have demonstrated that the active and biocompatible Au-Pt nanocomposites can be applied for preventing cell damages by scavenging cellular reactive oxygen species induced by ultraviolet irradiation, indicating potential uses for the prevention and therapy of ROS-mediated diseases. (C) 2013 Elsevier B.V. All rights reserved.
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