Journal
TALANTA
Volume 105, Issue -, Pages 333-339Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.talanta.2012.10.050
Keywords
Inkjet printing; Conducting polymers; Bioelectronics; Biosensors; Exocytosis
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Funding
- WCU (World Class University) program through the National Research Foundation of Korea
- Ministry of Education, Science and Technology [R31-10013]
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Polyaniline (PANi) patterns on flexible substrate are fabricated for biomolecule detection from live cells. PANi patterns are prepared by inkjet printing on polyethylene terephthalate film. Subsequently, arginine-glycine-aspartate (RGD) peptide is immobilized on the PANi pattern to selectively adhere cells. Rat pheochromocytoma PC12 cells are cultured on the RGD-immobilized PANi pattern, and patterned with high selectivity and growth. Additionally, the cells show focal adhesion on the RGD-immobilized PANi pattern, which are confirmed with vinculin staining and scanning electron microscopic images. To monitor dynamic biomolecular release from PC12 cells, RGD-immobilized PANi pattern is used for a real-time electrical signal detector. RGD-immobilized PANi patterning and sensing system represents outstanding ability to translate and amplify exocytosis molecules into a detectable signal as a transducer. (C) 2012 Elsevier B.V. All rights reserved.
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