Journal
TALANTA
Volume 88, Issue -, Pages 739-742Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.talanta.2011.11.046
Keywords
Microneedle biosensor; Microneedle; Multiplexed detection; Tumor microenvironment; Carbon paste
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Funding
- United States Department of Energy's National Nuclear Security Administration [DE-AC04-94AL85000]
- Div Of Chem, Bioeng, Env, & Transp Sys
- Directorate For Engineering [1066531] Funding Source: National Science Foundation
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The development of a microneedle-based biosensor array for multiplexed in situ detection of exercise-induced metabolic acidosis, tumor microenvironment, and other variations in tissue chemistry is described. Simultaneous and selective amperometric detection of pH, glucose, and lactate over a range of physiologically relevant concentrations in complex media is demonstrated. Furthermore, materials modified with a cell-resistant (Lipidure (R)) coating were shown to inhibit macrophage adhesion; no signs of coating delamination were noted over a 48-h period. (C) 2011 Elsevier B.V. All rights reserved.
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