Journal
TALANTA
Volume 93, Issue -, Pages 252-256Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.talanta.2012.02.029
Keywords
Gas-phase fragmentation; Host-guest complexes; Collision induced dissociation; Noncovalent interaction
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Funding
- National Natural Science Foundation of China [21027013]
- National High Technology Research and Development Program of China [2009AA03Z321]
- Tsinghua University
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Noncovalent interactions are ubiquitous in molecular interaction and supramolecular self-assembly. As a model system, host-guest complexes between beta-cyclodextrin (beta-CD) and small molecules have been extensively studied and widely used in a variety of application fields including drug transportation and fluorescence enhancement. However, details on how guest molecules interact with the beta-CD hosts to demonstrate the observed effects still remain to be further studied. In this work, we report the study of gas-phase fragmentation of host-guest complexes formed between beta-CD and small guest molecules by using collision induced dissociation (CID). The CID mass spectra of the complexes changed dramatically as the collision energy was increased. Fragmentation patterns of beta-CD complexed with different small molecules were analyzed and the differences in the presence/absence of fragment ions from the beta-CD were attributed to varied proton affinity of the small molecules. Furthermore, the CE50 values fitted from the fragmentation curves were used in the qualitative evaluation of interactions in noncovalent host-guest systems. (C) 2012 Elsevier B.V. All rights reserved.
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