Journal
TALANTA
Volume 96, Issue -, Pages 153-160Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.talanta.2012.02.018
Keywords
FIA; Pharmaceutical analysis; Tolterodine; Biological samples; Potentiometry
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Two new ion-selective electrodes of the plastic membrane type for the determination of Tolterodine (Tol) were prepared. These electrodes depend on the incorporation of the ion-exchangers of the above mentioned drug with phosphotungestic acid (PTA) or Silicotungestic acid (STA) in a PVC matrix. A comparative study is made between the performance characteristics of electrodes containing ion-exchanger in batch and FIA conditions. The usable concentration range of the electrodes was found to be (1.0 x 10(-5)-1.0 x 10(-2) and 5.0 x 10(-5)-1.0 x 10(-2) M) in batch and FIA conditions, respectively. The electrodes have nearly the same usable concentration, pH range and exhibited high selectivity toward Tol in the presence of many inorganic cations and can be used in biological fluids such as urine and plasma. The dissolution profile of the investigated drug as well as its assay in pure and pharmaceutical preparations was performed, and the results were relatively accurate and precise as indicated by the recovery values and coefficients of variation. (C) 2012 Elsevier B.V. All rights reserved.
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