Electrochemical behavior of azithromycin at graphene and ionic liquid composite film modified electrode

An electrochemical method has been successfully demonstrated for sensitive determination of azithromycin (Azi) with room temperature ionic liquid (IL) of 1-butyl-3-methylimidazolium hexafluorophosphate (BMIMPF6) - graphene (Gr) composite modified glassy carbon electrode (GCE). The cyclic voltammetric results indicate that Gr/IL/GCE can remarkably enhance electrocatalytic activity towards the oxidation of Azi in neutral solutions. Azi produce an anodic peak at about 0.82 Vat this electrode. The electrocatalytic behavior was further exploited as a sensitive detection scheme for the Azi determination by differential-pulse voltammetry (DPV). Under optimized conditions, the concentration range and detection limit were 0.49-28.57 mu g ml(-1) and 0.19 mu g ml(-1) (S/N = 3) respectively for Azi. The method was successfully applied assay of the drug in the pharmaceutical dosage forms. (C) 2011 Elsevier B.V. All rights reserved.