Journal
TALANTA
Volume 85, Issue 3, Pages 1338-1343Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.talanta.2011.06.017
Keywords
Melamine; Gold Nanoparticles; Milk; 3-Mercapto-1-propanesulfonate; Colorimetric probe
Categories
Funding
- National Natural Science Foundation of China [21075078]
- Natural Science Foundation of Shandong province, China [ZR2010BM005]
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A novel and sensitive colorimetric method for determination of melamine in milk samples was developed by a 3-mercapto-1-propanesulfonate-modified gold nanoparticles (MPS-GNPs) probe. Melamine molecule has multiple -NH(2) groups. These functional groups can interact with MPS to form strong hydrogen bonding and induce the aggregation of the MPS-GNPs, resulting in a dramatic color change from red to blue. Therefore, the concentration of melamine in milk samples can be quantitatively detected by the naked eyes or a UV-vis spectrometer. Moreover, investigations have revealed that the sensitivity of the detection could be clearly improved by adding NaCl to the modified GNPs solution, which leads to a more rapid color change in the NaCl-optimized GNPs system. It is worth noting that the absorption ratio (A(650)/A(520)) of the modified GNPs in the NaCl-optimized system exhibited a linear correlation with melamine concentration and the limit of detection is 8 nM, well below the safety limit (1 ppm for infant formula in China). (C) 2011 Elsevier B.V. All rights reserved.
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