Journal
TALANTA
Volume 85, Issue 1, Pages 157-166Publisher
ELSEVIER
DOI: 10.1016/j.talanta.2011.03.051
Keywords
Direct injection; Illicit drugs; Metabolites; Environmental water; LC-QqLIT-MS/MS; Green analytical chemistry
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Funding
- Spanish Ministry of Education and Science [CE-CSD2006-00044]
- Junta de Andalucia (Spain) [TEP2329]
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This work details a rapid analytical method using direct sample injection for the simultaneous identification/quantification of 22 drugs of abuse, including some of their major metabolites, in environmental samples. This has been developed using a hybrid triple quadrupole-linear ion trap-mass spectrometer (QqLIT). With the increasing sensitivity of today's tandem mass spectrometers, direct injection analysis of water samples has become an attractive alternative to traditional analytical protocols, which often include a preliminary pre-concentration step. What's more, this kind of analysis is in accordance with many of the main objectives of so-called green analytical chemistry, or environmentally friendly practice. The analytical performance of the LC-MS/MS method was evaluated in three different water matrices (surface water, influent and effluent wastewater). Data acquisition was carried out in selected reaction monitoring (SRM) mode under time-scheduled conditions, monitoring two SRM transitions for simultaneous identification/quantification of all target compounds in the samples. Additionally, an experiment was performed using the information-dependent acquisition (IDA) scan to carry out the identification of those analytes for which the second transition was present at a low intensity. Finally, the two methodologies developed were applied to real samples for evaluation. (C) 2011 Elsevier B.V. All rights reserved.
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