Cu nanoparticles incorporated polypyrrole modified GCE for sensitive simultaneous determination of dopamine and uric acid

Cu nanoparticles have been electrochemically incorporated polypyrrole film that was used for modification of the glassy carbon electrode surface. The performance of the electrode has been characterized by cyclic voltammetry and atomic force microscopy. The electrode has shown high electrocatalytic activity towards the oxidation of dopamine (DA) and uric acid (UA) simultaneously in a phosphate buffer solution (pH 7.00). The electrocatalytic oxidation currents of UA and DA were found linearly related to concentration over the range I x 10(-9) to I x 10(-5) M for UA and 1 X 10(-9) to 1 X 10(-7) M for DA using DPVs method. The detection limits were determined as 8 x 10(-10) M (s/n = 3) for UA and 8.5 x 10(-10) M (s/n = 3) for DA at a signal-to-noise ratio of 3. (C) 2009 Elsevier B.V. All rights reserved.