Journal
TALANTA
Volume 80, Issue 3, Pages 1378-1384Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.talanta.2009.09.039
Keywords
Capillary electrochromatography; Chiral separation; beta-Cyclodextrin; Derivative; Monolith
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Funding
- National Natural Science Foundation of China [20431030, 20671032]
- Ministry of Education of China [708029]
- Province Natural Science Foundation of Heilongjiang Province [ZJG0602-01]
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Based on combination of chiral recognition ability of beta-cyclodextrin (beta-CD) derivatives and flexibility of monolithic material, a series of chiral stationary phases (CSPs) were prepared by the immobilization of beta-CD and three of its derivatives to the epoxy-activated poly(glycidyl methacrylate-co-ethylene dimethacrylate) monolith under mild condition. Immobilization condition for the connection reaction by different functional groups and bonding ways was studied to obtain good enantiomer selectivity. Prepared CSPs were evaluated by separating racemic mixtures of eight amino acids and two chiral drugs with capillary electrochromatography (CEC). (C) 2009 Elsevier B.V. All rights reserved.
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