Journal
TALANTA
Volume 82, Issue 4, Pages 1164-1169Publisher
ELSEVIER
DOI: 10.1016/j.talanta.2010.06.036
Keywords
Direct electrochemistry; Cytochrome c; Macroporous gold; Hydrogen bubble template; Galvanic replacement reaction; Self-assembled monolayer
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Funding
- National Natural Science Foundation of China [20828006]
- National Science Fund for Creative Research Groups [20821063]
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We have successfully constructed a novel gold film with open interconnected macroporous walls of nanoparticles by combining the hydrogen bubble dynamic template synthesis with galvanic replacement reaction. After modified by a self-assembled monolayer (SAM) of 11-mercaptoundecanoic acid (MUA), the three-dimensionally (3D) interconnected macroporous Au film has been used as a biocompatible substrate for the immobilization of cytochrome c. The morphology, structure and electrochemical features of the modified and unmodified macroporous Au films were characterized by field-emission scanning electron microscopy (FESEM), energy-dispersive X-ray (EDX), cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS). The results reveal that the resultant films had a large electroactive surface area for high protein loading, enhanced electron transfer of cytochrome c, retained electrochemical activity, good stability and repeatability. And the excellent electrochemical behaviors could be attributed to the hierarchical structure of the macroporous Au film constructed by nanoparticles. (C) 2010 Elsevier B.V. All rights reserved.
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