Journal
TALANTA
Volume 78, Issue 2, Pages 327-332Publisher
ELSEVIER
DOI: 10.1016/j.talanta.2008.11.024
Keywords
Fe3O4 magnetic nanoparticles; Molecularly imprinted polymer; Estrone; Biochemical separation
Categories
Funding
- National Basic Research Program of China [2007AA10Z432, 2007CB914100]
- National Natural Science Foundation of China [20675040, 20875050]
- Natural Science Foundation of Tianjin [07JCYBJC00500]
- SRF
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In this study, we synthesized Fe3O4 magnetic nanoparticles coated estrone-imprinted polymer with controlled size using a semi-covalent imprinting strategy. In this protocol, the estrone-silica monomer complex (EstSi) was synthesized by the reaction 3-(triethoxysilyl)propyl isocyanate with estrone, where the template was linked to the silica coating on the iron oxide core via a thermally reversible bond. The removal of the template by a simple thermal reaction produced specific estrone recognition sites on the surface of silica shell. The resulting estrone-imprinted polymer coating Fe3O4 magnetic hybrid nanoparticles exhibit a much higher specific recognition and saturation magnetization. The hybrid nanoparticles have been used for biochemical separation of estrone. (c) 2008 Elsevier B.V. All rights reserved.
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